Dr. McNees is an associate of Dr. David Graham in the Department of Molecular Virology and Microbiology at the Baylor College of Medicine in Houston, TX. She talks about their methods to detect MAP in human subjects using culture and PCR, and discusses their results. MAP was detected in 70% of Crohn’s disease patients and 48.9% of controls. When the disease is in the colon, more cases are MAP-positive.
2017 MAP Conference | Treatment of MAP in a patient with Crohn’s Disease Followed by Disease Resolution
Dr. Shoor Vir Singh is a Principal Scientist at the Indian Council of Agricultural Research. He was unable to present at the 2017 MAP Conference due to a prior commitment, but has kindly provided his presentation materials. The presentation begins with an overview of MAP in India, and progresses to a detailed case study of a Crohn’s disease patient whose stool sample tested positive for Indian bison type MAP. After a year of antibiotic treatment, his Crohn’s disease symptoms had abated and MAP testing was negative. The antibiotic treatment regimen is detailed in Dr. Singh’s presentation. The final portion of the presentation describes treatment and control strategies for MAP in India, including an indigenous bison-type vaccine that is now available.
2017 MAP Conference | MAP Blood Culture and Diagnostic Testing
“Understanding Crohn’s disease is not rocket science — It is far more complex.” In this presentation, John Aitken from Otakaro Pathways in New Zealand discusses his efforts to reliably culture MAP from human patients. The issue of dormancy is outlined, along with the results of a recent testing study conducted with a 28 subject cohort. A mechanism is proposed for how MAP behaves to cause disease in the human population.
2017 MAP Conference | Virulence Factors as Potential Antigens for Serologic Tests
Dr. Bach is an Adjunct Professor in the Division of Infectious Diseases at the University of British Columbia in Vancouver, Canada. His research interests include understanding how pathogenic microorganisms successfully infect and multiply in humans, nanomedicine and antibody design. In his presentation, Dr. Bach discusses how MAP can survive in the macrophage and levels of antibodies found in Crohn’s patients vs. healthy control. Antibody levels are measured before and after traditional Crohn’s disease treatments are administered.
2017 MAP Conference | The Dark Art of MAP Culture
Dr. Bull is is a Senior Lecturer in Infectious Diseases and Associate Dean of the Biological Research Facility at St. George’s University of London. His presentation discusses his research on dormant forms of MAP and why cattle is the preferred host. He discusses factors which may activate MAP out of dormancy in vitro and what is known about the genetics and properties of human strains of MAP. Questions from the audience follow the presentation.