22 Apr 2017

2017 MAP Conference | Diagnosis of MAP Infection and Disease in Livestock

Dr. Kapur, of Penn State, looks at the prevalence and cost of MAP infection in cattle, and discusses the diagnostics available, which are a particular challenge. It’s difficult to get accurate, early testing, so MAP infection spreads, especially in large herds. Interestingly, Dr. Kapur has found that certain MAP proteins appear early on in infection (as early as 2-3 months), but then are detected less frequently in clinical disease.

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21 Apr 2017

2017 MAP Conference | Some Observations from Experimental Murine Infection with MAP

Dr. Marcel Behr is a Full Professor of Medicine and Fellow of the Canadian Academy of Health Sciences as well as the Director of the McGill International TB Centre and Microbiologist-in-Chief at the hospital. Here, Dr. Behr talks about the nature of MAP as compared to tuberculosis, and explains the challenges of finding MAP in human samples and why some testing for MAP gives false positives. He explains the gold standard of culture for human MAP and why MAP may not be present the feces. Questions from the audience follow the presentation.

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20 Apr 2017

2017 MAP Conference | Detecting Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn’s Disease Patients

Dr. McNees is an associate of Dr. David Graham in the Department of Molecular Virology and Microbiology at the Baylor College of Medicine in Houston, TX. She talks about their methods to detect MAP in human subjects using culture and PCR, and discusses their results. MAP was detected in 70% of Crohn’s disease patients and 48.9% of controls. When the disease is in the colon, more cases are MAP-positive.

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19 Apr 2017

2017 MAP Conference | Treatment of MAP in a patient with Crohn’s Disease Followed by Disease Resolution

Dr. Shoor Vir Singh is a Principal Scientist at the Indian Council of Agricultural Research. He was unable to present at the 2017 MAP Conference due to a prior commitment, but has kindly provided his presentation materials. The presentation begins with an overview of MAP in India, and progresses to a detailed case study of a Crohn’s disease patient whose stool sample tested positive for Indian bison type MAP. After a year of antibiotic treatment, his Crohn’s disease symptoms had abated and MAP testing was negative. The antibiotic treatment regimen is detailed in Dr. Singh’s presentation. The final portion of the presentation describes treatment and control strategies for MAP in India, including an indigenous bison-type vaccine that is now available.

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18 Apr 2017

2017 MAP Conference | MAP Blood Culture and Diagnostic Testing

“Understanding Crohn’s disease is not rocket science — It is far more complex.” In this presentation, John Aitken from Otakaro Pathways in New Zealand discusses his efforts to reliably culture MAP from human patients. The issue of dormancy is outlined, along with the results of a recent testing study conducted with a 28 subject cohort. A mechanism is proposed for how MAP behaves to cause disease in the human population.

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17 Apr 2017

2017 MAP Conference | Virulence Factors as Potential Antigens for Serologic Tests

Dr. Bach is an Adjunct Professor in the Division of Infectious Diseases at the University of British Columbia in Vancouver, Canada. His research interests include understanding how pathogenic microorganisms successfully infect and multiply in humans, nanomedicine and antibody design. In his presentation, Dr. Bach discusses how MAP can survive in the macrophage and levels of antibodies found in Crohn’s patients vs. healthy control. Antibody levels are measured before and after traditional Crohn’s disease treatments are administered.

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