Posts by: Moderator

MAP and Crohn’s disease: A Review of the Recent ACDP Position | Web Admin

Virus MicrographOn February 26, 2015, the Advisory Committee on Dangerous Pathogens in the United Kingdom published a review of the latest research on the possible link between Mycobacterium avium, subspecies paratuberculosis (MAP) and Crohn’s disease. The last such review, conducted in 2005, determined that there was no evidence to connect MAP to Crohn’s disease. That was not the finding in the current review done a decade later. Read on to see what the ACDP found.

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Dr. William Chamberlin: 2015 Crohn’s Research Symposium Introduction

In this first video, Dr. William Chamberlin presents an overview of Crohn’s disease and outlines the research supporting a causal role by Mycobacterium avium ssp paratuberculosis. This is just a preview of things to come. Additional videos will be available shortly.

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Dr. Michael Collins: Crohn’s Disease and the Farm

Dr. Collins, a veterinarian from the University of Wisconsin in Madison, discusses the crossover between human medicine and animal medicine. He makes a compelling argument that the MAP bacteria cross from cattle to humans and should be recognized as a zoonotic infection.

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Crohn’s Disease and MAP: Patrick McLean

Patrick Mclean symposiumPatrick McLean discusses the research surrounding MAP and it’s relationship to Crohn’s disease. He presents study results that provide strong evidence that MAP may be a causative agent in Crohn’s disease.

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Dr. Amy Hermon-Taylor: MAP Diagnostics

Dr Amy Hermon-Taylor at the Crohn's disease SymposiumDr. Amy Hermon-Taylor discusses the need for a specific diagnostic process to isolate the MAP infection in patients with Crohn’s disease. Without a specific, fast and reliable diagnostic process or procedure, MAP will continue to be an unconfirmed causative agent in Crohn’s disease.  If it can’t be measured, it can’t be controlled.

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John Aitken: The Microbiology of MAP

John Aitken, a laboratory scientist from New Zealand, discusses Mycobacterium avium ssp paratuberculosis from a microbiological perspective. Find out what we know about this organism and how it behaves. See never before released photos of the organism, learn why Mr. Aitken calls this “Son of MAP” and how his research will help Crohn’s disease patients.

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Dr. William Chamberlin: EpiBro and Crohn’s Disease

Dr. William Chamberlin discusses the dysfunctional immune response of Crohn’s disease patients and a new treatment that is in development to remedy this genetic malady. EpiBro is a synthetic steroid, and it attempts to fix the dysfunction in Crohn’s disease by enhancing the innate immune response. Dr. Chamberlin terms it “Prednisone without the side effects.” Hear the story of how this drug, initially developed to treat AIDS infections, could now be utilized to help Crohn’s disease patients as well.

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Dr. Amy Hermon-Taylor: The MAP Vaccine

Dr. Amy Hermon-Taylor talks about the MAP Vaccine that her father’s lab is developing.  She gives a clear explanation of how the vaccine will work to treat Crohn’s disease patients and discusses the timeframe and steps required for approval. Includes engaging questions from the audience!

Dr. David Rubin: MAP, the Microbiome and Crohn’s Treatment

A welcome surprise to the symposium lineup, Dr. David Rubin, section chief of the department of gastroenterology at the University of Chicago Medical Center, discusses the current state of Crohn’s disease and outlines some of the available treatments. While he prescribes Anti-MAP therapy for some of his patients, he takes an individualistic approach to care, utilizing all treatment available to manage his patients’ disease. Interesting information about the role of the gut microbiome, the genetic profile of Crohn’s patients and how Dr. Rubin became interested in gastroenterology are included. He admits that the search for a cure should be a goal of current IBD research. Don’t miss the insightful audience questions!

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John Aitken – Antibiotics

AntibioticsWe are at the dawning of a new era in the use of antibiotics. For some 20 years there have been attempts to use antibiotics in the treatment of Crohn’s disease. Although most trials have delivered mixed results, this direction has been reinforced by the association of Mycobacterium avium ssp paratuberculosis (MAP) with Crohn’s disease. The main principle of judicious and effective antibiotic usage has been the targeting of the suspected pathogen with a therapy that is both specific and directed.  This has been a difficult job, as there has been, up to now, no protocol that will ensure the reliable isolation of the pathogen from the patient. The model that is used for new compounds against MAP-associated organisms is directly related to the proven therapies for tuberculosis, and this has been a wise model to follow.

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