Here, Dr. Harry Oken presents the case of a middle-aged patient with a history of depression and hypothyroidism who had unusual symptoms, including one-sided allodynia, “pins and needles” sensation, headaches, joint pain, periodic night sweats and IBS symptoms. Treatments included a therapeutic trial of steroids, which caused a steroid psychosis and led to inpatient psychiatric hospitalization, culminating in 25+ Electroconvulsive treatments. A blood culture was positive for an atypical Mycobacteria and a three drug antibiotic regimen was begun with dramatic sustained improvement.