Patrick McLean discusses the research surrounding MAP and it’s relationship to Crohn’s disease. He presents study results that provide strong evidence that MAP may be a causative agent in Crohn’s disease.
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Dr. Amy Hermon-Taylor discusses the need for a specific diagnostic process to isolate the MAP infection in patients with Crohn’s disease. Without a specific, fast and reliable diagnostic process or procedure, MAP will continue to be an unconfirmed causative agent in Crohn’s disease. If it can’t be measured, it can’t be controlled.
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John Aitken, a laboratory scientist from New Zealand, discusses Mycobacterium avium ssp paratuberculosis from a microbiological perspective. Find out what we know about this organism and how it behaves. See never before released photos of the organism, learn why Mr. Aitken calls this “Son of MAP” and how his research will help Crohn’s disease patients.
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Dr. William Chamberlin discusses the dysfunctional immune response of Crohn’s disease patients and a new treatment that is in development to remedy this genetic malady. EpiBro is a synthetic steroid, and it attempts to fix the dysfunction in Crohn’s disease by enhancing the innate immune response. Dr. Chamberlin terms it “Prednisone without the side effects.” Hear the story of how this drug, initially developed to treat AIDS infections, could now be utilized to help Crohn’s disease patients as well.
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Dr. Amy Hermon-Taylor talks about the MAP Vaccine that her father’s lab is developing. She gives a clear explanation of how the vaccine will work to treat Crohn’s disease patients and discusses the timeframe and steps required for approval. Includes engaging questions from the audience!
A welcome surprise to the symposium lineup, Dr. David Rubin, section chief of the department of gastroenterology at the University of Chicago Medical Center, discusses the current state of Crohn’s disease and outlines some of the available treatments. While he prescribes Anti-MAP therapy for some of his patients, he takes an individualistic approach to care, utilizing all treatment available to manage his patients’ disease. Interesting information about the role of the gut microbiome, the genetic profile of Crohn’s patients and how Dr. Rubin became interested in gastroenterology are included. He admits that the search for a cure should be a goal of current IBD research. Don’t miss the insightful audience questions!
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We are at the dawning of a new era in the use of antibiotics.
For some 20 years there have been attempts to use antibiotics in the treatment of Crohn’s disease. Although most trials have delivered mixed results, this direction has been reinforced by the association of Mycobacterium avium ssp paratuberculosis (MAP) with Crohn’s disease.
The main principle of judicious and effective antibiotic usage has been the targeting of the suspected pathogen with a therapy that is both specific and directed. This has been a difficult job, as there has been, up to now, no protocol that will ensure the reliable isolation of the pathogen from the patient. The model that is used for new compounds against MAP-associated organisms is directly related to the proven therapies for tuberculosis, and this has been a wise model to follow.
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I know everyone is patiently awaiting the video replay from the symposium last week, and we hope to get it on the website this week! Also coming soon: a MAP forum partnership where you can share your stories, treatments, theories and ideas about everything MAP. Sign up and stay connected to the latest developments and others like you. While we wait for the video, here are a few thoughts from a humble audience member.
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About Crohn’s Treatments Traditional Treatments Prednisone 6-MP and AZA Methotrexate Remicade HUMIRA Biosimilars Anti-MAP (AMAT) Therapy Anti-MAP Q&A Clinical Trials Patient Stories A Pediatric Story 3 Stories of Hope David Elle Jay Jen Roy M. Resources Core Research Pack CD vs. UC Chart The MAP Map Scroll in the window or hover in the right ...
Immune Modulating Drug Stimulates Innate Immunity, Down-Regulates Unproductive Inflammation and Promotes Th1 Immunity People have asked for more information on Formulated EpiBro (FepiBro). A formulation of 16-bromoepiandrosterone (Epi-Br) was originally developed and investigated under the name HE2000. There is extensive literature on its activity against infectious diseases. It underwent human trials as an immune modulating drug designed to combat the major infectious diseases in the “Developing World.” The HE2000 formula demonstrated activity against HIV/AIDS, malaria and tuberculosis in nine human trials. It was shown to be safe and effective. Read on to see why it wasn’t further developed and why it could now help Crohn’s disease patients.