MAP: In vitro Adaptation to Anaerobiosis, Differential Susceptibility to Antibiotics, and Implications for Therapy
by Dr. Nicole Parrish and Dr. Neil Goldberg
Dr. Nicole Parrish of the Johns Hopkins School of Medicine and Dr. Neil Goldberg of the University of Maryland begin the presentation by discussing tuberculosis and the Wayne Model of Non-Replicating persistence and how that model relates to MAP latency. Their research shows that MAP can convert from an aerobic (oxygen using) state to an anaerobic (non-oxygen) state similar to that seen in tuberculosis. The presentation concludes with a discussion of MAP antibiotic susceptibility and a case study where a combination of antibiotics led to cessation of Crohn’s disease and pyoderma gangrenosum.